Drug Induced Onycholysis

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Diclofenac-Induced Photo-Onycholysis.

Onycholysis is the detachment of the nail plate from the nail bed. If drug-induced, it can be an isolated phenomenon, but it may also accompany or follow a cutaneous phototoxicity reaction due to drug intake and exposure to ultraviolet irradiation. Photo-onycholysis is a rare photosensitivity reaction due to exposure to either a natural or artificial source of light. Many drugs are responsible ...

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Photo-onycholysis: two cases induced by doxycycline.

Photo-onycholysis is a phototoxic reaction, which is usually drug-induced. It consists of the separation of the nail from the nail bed due to ultraviolet radiation. We report two cases of female patients who developed distal onycholysis while receiving doxycycline. Among the drugs that cause photo-onycholysis, the most frequently cited are tetracyclines, psoralens and fluoroquinolones. Photo-on...

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Docetaxel-Induced Onycholysis: The Role of Subungual Hemorrhage and Suppuration

Nail changes are common side effects of taxane chemotherapeutic agents. Docetaxel (Taxotere) is known to cause a great incidence of nail change. Various types of nail changes have previously been reported as a result of treatment with taxanes. We describe 2 cases of severe nail changes induced by docetaxel. The patients had previously been diagnosed with breast cancer and advanced gastric cance...

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Nail pitting and onycholysis.

A previously healthy man, 43 years of age, was referred to the dermatology department with a one-year history of fingernail onychomycosis. His condition was refractory to oral antifungal treatment (terbinafine 250 mg QD for three months). On physical examination, nail pitting and onycholysis affecting seven fingernails was noted (Figure 1A). He also had mild erythematous silvery-white scaly pat...

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Periarticular Thenar Erythema and Onycholysis Syndrome: A Manifestation of Taxane-Induced Cutaneous Toxicity.

In recent years, the widespread use of taxane-based chemotherapy regimens for the management of malignant tumors of various origins has evidenced the high frequency of cutaneous toxicity induced by this pharmacological group. In 2003, among its possible manifestations, Childress and Lokich defined periarticular thenar erythema and onycholysis (PATEO) syndrome as a rare subtype of hand-foot synd...

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ژورنال

عنوان ژورنال: Clinical Dermatology Open Access Journal

سال: 2017

ISSN: 2574-7800

DOI: 10.23880/cdoaj16000114